Based on the formation of carbodiimide compounds between carboxyl and primary amines, hollow microspheres arising fromthe\nfolic acid (folate-FA) grafted onto the surface of the modified hydroxyapatite were successfully prepared.The hollow morphology\nand composition of the FA-grafted hydroxyapatitemicrosphereswere confirmed by scanning electronmicroscopy (SEM) and other\ncharacterizations. Brunauer-Emmett-Teller (BET) assay revealed the specific surface area and average pore size of the microspheres\nwere 34.58m^2/g and 17.80 nm, respectively. As a drug carrier, the kinetic investigation of doxorubicin (DOX) loaded shows that the\nadsorbed behavior of drug on the adsorbent is more suitable to be described with pseudo-first-order model. Furthermore, the\nrelease rate can reach 83% at pH 5.7, which is greater than the release of 39% at pH 7.4, indicating an excellent performance of\ncontrolled drug release for response pH. The releasemechanismof DOX coincides with Fickian diffusion as a result of Korsmeyer-\nPeppas model analysis and the release phenomena can be well explained by Fickian diffusion second law.
Loading....